Son of sevenless homolog 1 sos1
WebNov 1, 2011 · The SOS1 gene encodes the Son of Sevenless 1 protein, a Ras and Rac guanine nucleotide exchange factor. This protein is composed of several important … WebSon of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins …
Son of sevenless homolog 1 sos1
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WebThe SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. WebApr 10, 2024 · KRAS mutations (G12C, G12D, etc.) are implicated in the oncogenesis and progression of many deadliest cancers. Son of sevenless homolog 1 (SOS1) is a …
WebRecombinant Human SOS1. Son of Sevenless Homolog 1. SOS1 is a guanine nucleotide exchange factor (GEF) for RAS proteins, which are membrane associated proteins involved in various signaling pathways. RAS proteins are activated by GEF-facilitated GDP exchange for GTP, and inactivated by GTP hydrolysis. RAS signaling is upregulated in many ... WebSon of sevenless homolog 1. Gene. Sos1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Mus musculus (Mouse) Amino acids. 1319. Protein existence. Evidence at …
WebApr 1, 2024 · Son of sevenless homolog 1 (SOS1) is a key regulator of KRAS to modulate KRAS from inactive to active states. Herein, we disclosed efficacy-improving tetra-cyclic quinazoline derivatives as an ...
WebFeb 10, 2024 · Figure 10 shows that EGCG downregulated proinflammatory PI3K-AKT genes, which are as follows: Son of sevenless homolog 1 (Drosophila) (SOS1), Raf proto-oncogene serine/threonine-protein kinase aka proto-oncogene c-RAF (RAF1), Beta-Glucuronidase (GUSB), Insulin-Like Growth Factor I receptor (IGF1R), Cyclin-dependent kinase inhibitor …
WebFeb 1, 2024 · Herein, the expression of miR-148b-3p and son of sevenless homolog 1 (SOS1) both in OS tissues and cells were examined using quantitative real-time polymerase chain reaction and Western blotting ... chimney swifts are small slender birdsWebGTPase HRasSon of sevenless homolog 110-[(4-fluorophenyl)methyl]-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoleMAGNESIUM IONPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER. NCBI. National Center for Biotechnology Information. Search. ... SON of Sevenless Homolog 1 (Gene symbol: SOS1) Chemicals and Non-standard … chimney swifts in my chimneyWebWe aimed to explore the role and mechanism of SOS1 (Son of sevenless homolog 1) in malignant behaviors of epithelial ovarian cancer (EOC) cells Hey with high metastatic … chimney swifts chapel hill ncWebBlocking the interaction between Ras and Son of Sevenless homolog 1 (SOS1) has been an attractive therapeutic strategy for treating cancers involving oncogenic Ras mutations. K … chimney swifts going into chimneyWebDec 2, 2024 · SOS1, son of sevenless homolog 1: The guanine nucleotide exchange factor is the protein encoded by this gene. RAS proteins are membrane proteins that interact with guanine nucleotides and engage in signaling cascades. Gingival fibromatosis type 1 and Noonan syndrome type 4 are related to mutations in this gene [42]. chimney swift sweeps mercerville njWebSon of sevenless homolog 1 (1333 aa, ~152 kDa) is encoded by the human SOS1 gene. This protein is involved in the mediation of guanine nucleotide exchange for RAS superfamily … chimney swifts ncWebSon of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins by mediating the exchange of GTP to GDP. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed ... gradygirl productions