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WebAnticancer: Vincristine, Methotrexate, Tamoxifen; PDE inhibitors: Sildenafil* Heavy metals: Lead*, Mercury, Thallium; Other: Carbon Monoxide, Tobacco * Please see Pathophysiology for selected drug mechanism and … WebNov 1, 2024 · Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral granulomatous panuveitis associated with serous retinal detachments and vitritis, and can be associated with extraocular manifestations of meningismus, poliosis, vitiligo, hearing loss, and headaches. It is mediated by CD4+ T cells that target melanocytes in the eye, ear, … WebThe mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. dr anthony eyers