WebDrug type: VP-16 is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase II inhibitor." (For more … WebCisplatin [CAS No. 15663-27-1] is an alkylating agent used as a chemotherapy drug, available as a pharmaceutical secondary standard and certified reference material for …
Etoposide (Toposar®, VePesid®, Etopophos®,VP-16) - Oncolink
WebJun 9, 2024 · About: Etoposide (Toposar®, VePesid®, Etopophos®,VP-16) Etoposide works by blocking the action of an enzyme in cells called topoisomerase, which is necessary for cell replication and tumor growth. Cells need this enzyme to keep their DNA in the proper shape when they are dividing. WebSep 25, 2024 · Standard-of-care first-line treatment for extensive-stage small-cell lung cancer is platinum chemotherapy (carboplatin or cisplatin) with etoposide. 1-3 Despite response rates of 60 to 65%,... helena bonham carter photos
Non-Small Cell Lung Cancer Treatment Regimens
WebCisplatin and VP-16 were used to study the induction of apoptosis in Panc-1 cells. Cisplatin and VP-16 inhibited the growth of Panc-1 cells. After 2 hours exposure to cisplatin or VP-16, attached and detached cells were subjected to TUNEL staining to calculate the ratio of apoptosis. WebThe cisplatin-VP16 (PE) regimen was used in 13 pts, and 9 of them (69%) obtained objective responses after chemotherapy (CT) alone, with 3 complete remissions (CR) and 6 partial remissions (PR). Median CR and PR duration was 13+ and 24 months, respectively. Radiotherapy was performed in 7/13 pts after induction CT and before consolidation CT. WebThirty-one patients with small-cell lung cancer (SCLC) were treated with VP-16 and cisplatin as first-line therapy. In the majority of cases an Adriamycin (Adria Laboratories, … helena bonham carter shoes